JUN 10 

Moringa and MicroplasticsBisphenol A (BPA) is defined as a synthetic high production monomer utilized in polycarbonate plastics and the resins of epoxy in consumer products. These products are used in canned beverages and food, bottles made of plastic, plastic food containers, thermal receipts, plastic medical equipment, and various plastic consumer products used in other applications. BPA leads to hepatotoxic effects, mutagenic features for DNA, carcinogenic effects, and direct effects on the reproductive system, causes DNA strand breaks, induces liver lesions, kidney tissue changes with brain injuries and other organs with histopathological changes by generating reactive oxygen species.Moringa oleifera is a fast-growing evergreen tree. It’s leaf powder is rich in various minerals, such as iron, vitamin A, and vitamin C, which are significant to iron metabolism. M. oleifera is indicated to be utilized in the treatment of different diseases, including rheumatism and ascites, as well as viral diseases (e.g., influenza virus), bacterial infections, different types of abscess, has the ability to reduce hyperglycemia effect and dyslipidemia, prevents DNA damage in mice and promotes hepatic glutathione restoration.One study aimed to estimate the leaf extract of M. oleifera against hepatotoxicity induced by BPA44 adult male rats were used in the study, 11 groups (4 animals per group). The rats were administrated (orally) with 5 and 10 mg/kg BPA and treated (orally) with 100, 200, 300, and 400 mg/kg of the aqueous extract of M. oleifera. After 28 days of challenge, liver enzymes, including aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as a pathological study using the liver tissue sections were determined. The findings showed a significant increase in the AST, ALT, and ALP in the BPA groups with different histological changes that included the sclerosis of the bile duct surrounded by fibrocytes and lymphocytes infiltration. After treatment with M. oleifera, the liver enzymes and tissue returned to a normal state and showed non-significant differences, compared to the control group. The aqueous extract of M. oleifera has a great potential to prevent and improve liver damage of BPA.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759219/