GEERT VANDEN BOSSCHE APR 03, 2024 READ
What we will eventually observe is that this highly effective process of viral adaptation will ultimately confer an absolute fitness advantage to a Coronavirus (CoV) that is both structurally and functionally completely different from SARS-CoV-2 (SC-2) and its variants. It will be featured by many changes in spike and other viral proteins and have additional O-glycosylation sites while being resistant to neutralizing antibodies (Abs), virulent and highly productive/ replicative. It will use polyreactive nonneutralizing Abs (PNNAbs) to cause Ab-dependent enhancement of infection, thereby causing enhancement of severe disease (basically, as a result of rapid virus dissemination and replication in all organs). It will spread as a ‘strange’ but dominating lineage as a kind of ‘extraterrestrial dictator’ that outcompetes all previously circulating SC-2 lineages.