Evidence supporting previous Friday Hope hypotheses.

WALTER M CHESNUT OCT 6, 2023 READ

We reported that exposure of the virus to green tea, roasted green tea, oolong tea and black tea in vitro resulted in significant reduction of the virus infectivity16,17,18. We also found that the tea catechin compound (−)- epigallocatechin gallate (EGCG) powerfully and rapidly inactivated the virus16,17,18, which was also reported by other groups19,20,21. Similar effects were also seen in black tea ingredients, galloylated theaflavins (theaflavin-3-O-gallate (TF3G), theaflavin-3’-O-gallate (TF3’G), and theaflavin-3,3’-O-digallate (TFDG)), and theasinensin A (TSA) that are derivatives of tea catechins17,22. We also reported that the EGCG, TFDG and TSA interfered with the interaction between viral spike protein and ACE2 by binding to the spike protein receptor binding domain (RBD).