Geert Vanden Bossche July 19, 2022
What are the mechanism(s) that (largely) bypass the innate immune system upon vaccination with non-replicating vaccines (like mRNA)? Is this simply because it is a localized injection that doesn’t replicate/spread throughout other tissues and organs? Or is this due to additives in mRNA vaccines that prevent innate immune stimulation in order for the mRNA itself to not be degraded before being absorbed into target cells?
Only replicating virus will present virus-derived (self-mimicking)motifs/patterns (on the surface of infected cells) that can be recognized by innate effector cells (NK cells).
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